HLA Type Variation Across Populations

Background: Human Leukocyte Antigen (HLA) is highly polymorphic and it commonly used as a marker for core population genital aspects such human migration, predisposition to diseases in tissue transplantation compatibility. Methodology: For our study authors have taken up sample size of 86 meta- analysis high-resolution frequency data the HLA allele. North Indian patients from tertiary centre were analyzed identification HLA-A, B, C, DRB1 DQB1 alleles by sing serological molecular typing techniques. A plethora known identified at different loci e.g., 18, B 36, C 5, 28 8. This focusing on frequencies their homozygosity heterozygosity been reported, but living Delhi, Haryana, Uttarakhand , Uttar Pradesh, Punjab Himachal are reported here characterized. Allele using Hardy-Weinberg equilibrium. Results: was observed 96.51% individuals locus 97.67% HLA-B HLA-DRB1,overallheterozygosity all three 89.5% (77/86 individuals). Among showing (9 individuals), two showed loci. Conclusion: The increased class 1 2 associated with selective advantage against infectious diseases. phenotypic B*35 (B*35:01, B*35:03 B*35:08) 31.39%. Comparable allele (27.5%) north patients.